1.
RSC Adv
; 13(45): 31891-31896, 2023 Oct 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37915442
RESUMO
The manuscript describes the highly regioselective 6-exo-dig iodo/bromo cyclization of functionalized N-propagyl-amino-pyrimidinones under ambient conditions. The cyclization afforded functionalized pteridines in excellent yields. The optimized procedures are mild, operationally simple and working successfully with different substrates. The synthesis of functionalized pteridines is of great significance because of their potential pharmacological profile.